The Salmonella typhi IgM (TYPHI DOT) test is a diagnostic tool used to detect the presence of antibodies against Salmonella typhi bacteria in a patient’s blood. This test is commonly used to diagnose typhoid fever, a bacterial infection caused by Salmonella typhi. The TYPHI DOT test works by detecting specific IgM antibodies produced by the immune system in response to a recent Salmonella typhi infection. The test is highly sensitive and specific, making it a useful tool for early diagnosis and treatment of typhoid fever. However, it is important to note that the test may produce false negative results in the early stages of infection or in patients who have received antibiotics prior to testing.